Example phosphoproteomics differential expression results — combined_test_diff

Combined differential expression results from phosphoproteomics analysis of Atg16l1 knockout vs wild-type macrophages. Contains both site-level (DPA) and protein-corrected (DPU) statistics for 4 contrasts.

Usage

combined_test_diff_example

Format

A tibble with 105,824 rows and 56 columns including:

protein_Id: UniProt protein identifier
gene_name.site: Gene symbol
modAA: Modified amino acid (S, T, or Y)
posInProtein: Position of modification in protein
SequenceWindow: Flanking sequence around modification site
contrast: Comparison name (e.g., KO_vs_WT)
diff.site: Log2 fold change for site (DPA)
statistic.site: t-statistic for site
p.value.site: p-value for site
FDR.site: FDR-adjusted p-value for site
diff_diff: Protein-corrected log2 fold change (DPU)
tstatistic_I: t-statistic for DPU
pValue_I: p-value for DPU
FDR_I: FDR-adjusted p-value for DPU

Source

Maculins et al. (2020) eLife, doi:10.7554/elife.62320