Compute MSstats-like test statistics for differential PTM usage

Joins site-level and protein-level results, computes difference-of-differences, and performs t-tests for differential PTM usage.

Usage

test_diff(
  phos_res,
  tot_res,
  join_column = c("protein_Id", "contrast", "description", "protein_length",
    "nr_tryptic_peptides")
)

Arguments

phos_res

Data frame with phospho site-level results

tot_res

Data frame with protein-level results

join_column

Character vector of columns to join by

Value

Data frame with combined results including diff_diff test statistics